ANCIENT WISDOM. MODERN SCIENCE.
Not Just Natural.
Clinically Proven.
Three independent studies. Two world-class institutions. Zero adverse events. Here is every result, in full.
CLINICAL EVIDENCE
3
independent studies
240
subjects tested
98.6%
non-irritant viability
0
adverse events
12M
stability confirmed
Repeated Insult
Patch Test
EUROFINS | CRL, INC. · PISCATAWAY, NJ
The gold standard for dermal safety. 240 male and female subjects aged 18–70, including 109 with self-perceived sensitive skin, underwent a full Repeated Insult Patch Test conducted to ICH GCP standards. Overseen by Winston Moy, MD — Diplomate of the American Board of Dermatology.
study 01
FIELD | DETAIL |
|---|---|
Study Number | ECRLNJ2025-0577 |
Study Type | Repeated Insult Patch Test (RIPT) |
Subjects | 240 (male & female, ages 18–70) |
Sensitive Skin | 109 of 240 subjects |
Fitzpatrick Types | I through VI — full range |
Ethnicities | Caucasian, AA, Hispanic/Latino, Asian, Indian |
Principal Investigator | Winston Moy, MD — American Board of Dermatology |
Standard | ICH GCP |
Adverse Events | ✓ None reported |
Protocol Deviations | ✓ None |
Study Period | June 13 – August 8, 2025 |
0
Adverse Events
ACROSS 240 SUBJECTS
· INCLUDING 109 SENSITIVE SKIN
"
The test material identified
as Hirudin Topical Serum
did not demonstrate a
potential for eliciting dermal
irritation or inducing
sensitization.
official study conclusion
EUROFINS | CRL, INC.
Skin Irritation Test
OECD 439
LIFENET HEALTH LIFESCIENCES · KALAMAZOO, MI
Conducted using the internationally validated MatTek EpiDerm™ reconstructed human epidermis model — the same system used by global cosmetic brands and accepted as a regulatory standard in the EU, US, and worldwide. Our product scored nearly double the required threshold for Non-Irritant classification.
study 02
FIELD | DETAIL |
|---|---|
Study Period | June 2025 |
GHS Classification | ✓ No Category — Non-Irritant to Skin |
Our Result | 98.6% — nearly double threshold |
Non-Irritant Threshold | Mean viability >50% |
Mean Tissue Viability | 98.6% ± 4.5% |
Test Concentration | 2% Neat (commercial concentration) |
Principal Investigator | Jamin A. Willoughby, Sr., Ph.D. |
Test Model | MatTek EpiDerm™ reconstructed human epidermis |
Standard | OECD Test Guideline 439 |
Study Number | LNH-S-095-003 |
98.6%
Tissue Viability
NON-IRRITANT THRESHOLD IS 50%
· PRODUCT SCORED 98.6%
12 Week Cosmetic
Stability Study
EUROFINS | CRL, INC. · PISCATAWAY, NJ
study 03
Rigorous accelerated stability study at 40°C / <60% RH — simulating extended real-world aging. Every key parameter evaluated at 3-week intervals including pH, viscosity, colour, texture, microbial count, and full preservative efficacy against five challenge organisms.
Parameter | Ambient | Stress | Status |
|---|---|---|---|
Colour | No Change | No Change | ✓ Pass |
Odour / Fragrance | No Change | No Change | ✓ Pass |
Texture | No Change | No Change | ✓ Pass |
Weight | No Change | No Change | ✓ Pass |
Package Integrity | No Change | No Change | ✓ Pass |
pH | 5.61 (Δ0.01) | 5.45 (Δ0.17) | ✓ Pass |
Viscosity | 73.0 (stable) | 62.4 (acceptable) | ✓ Pass |
Preservative Efficacy | All 5 organisms eliminated within 7 days at every interval | All 5 organisms eliminated within 7 days at every interval | ✓ Pass |
Safe For Most.
Important Notes For Some.
SAFETY GUIDANCE
⚠
Anticoagulant Medications
Do not use if taking prescription anticoagulants (warfarin, heparin, apixaban) without consulting a healthcare professional first.
⚠
Pregnancy & Breastfeeding
Consult a healthcare professional before use if pregnant or breastfeeding.
✓
Sensitive Skin
Clinically confirmed safe. 109 of 240 study subjects had self-perceived sensitive skin. Zero adverse events across the entire sensitive skin group.
✓
All Skin Tones
Tested across Fitzpatrick types I–VI, representing Caucasian, African American, Hispanic/Latino, Asian, and Indian skin types.
✓
External Use Only
Topical application only. Avoid eyes and mucous membranes. Keep out of reach of children.
✓
Storage
Room temperature. Protect from direct sunlight. 12-week stability confirmed under 40°C / <60% RH.
This product is a cosmetic serum and is not intended to diagnose, treat, cure, or prevent any disease or medical condition. Statements represent the findings of independent third-party clinical testing. Results may vary.